The Holy See is worried that Israel might make decisions that could potentially jeopardize diplomatic dialogue.
The first cure in Lourdes, France, was reported in 1858 and 70 healings since have been deemed miraculous.
He will also pray the Regina Coeli from the window in the Apostolic Palace, the first time since March.
He signed a new law requiring transparency in awarding contracts for goods and services, in an effort to prevent corruption and save resources.